Publications

2020

  • Zosel F, Soranno A, Nettels D, Schuler B. Depletion interactions modulate coupled folding and binding in crowded environments. arXiv preprint arXiv:1912.06783
  • Martin EW, Holehouse AS, Peran I, Farag M,  Incicco JJ, Bremer A, Grace CR, Soranno A, Pappu RV, Mittag T. Valence and patterning of aromatic residues determine the phase behavior of prion-like domains. Science 367 (6478), 694-699

2019

  • Soranno A. The Trap in the FRAP: A Cautionary Tale about Transport Measurements in Biomolecular Condensates. Biophys. J.
  • Singh SP, Soranno A, Sparks MA, Galletto R. Branched unwinding mechanism of the Pif1 family of DNA helicases. Proc. Natl. Acad. Sci. USA.

2018

  • Soranno A, Zosel F,Hofmann H. Internal friction in an intrinsically disordered protein—Comparing Rouse-like models with experiments. J. Chem. Phys.
  • Soranno A, Cabassi F, Orselli ME, Cellmer T, Gori A, Longhi R, Buscaglia M Dynamics of Structural Elements of GB1 β-Hairpin Revealed by Tryptophan–Cysteine Contact Formation Experiments. J. Phys. Chem. B 122 (49), 11468-11477 
  • Rezaei-Ghaleh N, Parigi G, Soranno A, Holla A, Becker S, Schuler B, Luchinat C, Zweckstetter M, Local and Global Dynamics in Intrinsically Disordered Synuclein, Angew.Chemie
  • Borgia A, Borgia MB, Bugge K, Kissling VM, Heidarsson PO, Fernandes CB, Sottini A, Soranno A, Buholzer KJ, Nettels D, Kragelund BB, Best RB, Schuler B. Extreme disorder in an ultra-high-affinity protein complex, Nature

2017

  • Best RB, Borgia A, Zheng W, Buholzer K, Borgia MB, Hofmann H, Soranno A, Nettels D, Gast K, Grishaev A and Schuler B, Comment on “Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water”, Science 361 (6405)
  • Soranno A, Holla A, Dingfelder F, Nettels D, Makarov D and Schuler B. Integrated view of internal friction in unfolded proteins from single-molecule FRET, contact quenching, theory, and simulations Proc. Natl. Acad. Sci. USA.
  • Zosel F, Haenni D, Soranno A, Nettels D and Schuler B. Combining short- and long-range fluorescence reporters with simulations to explore the intramolecular dynamics of an intrinsically disordered protein. J. Chem. Phys. (2017)

2016

  • Soranno A, Holla A, Dingfelder F, Nettels D, Makarov DE, Schuler B,Integrated view of internal friction in unfolded proteins from single-molecule FRET, contact quenching, theory, and simulations Proc. Natl. Acad. Sci. USA. (2016)
  • Borgia A, Zheng W, Buholzer K, Borgia MB, Schüler A, Hofmann H, Soranno A, Nettels D, Gast K, Grishaev A, Best RB, Schuler B, Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods, J. Am. Chem. Soc. (2016)
  • Aznauryan M, Delgado L, Soranno A, Nettels D, Huang J, Labhardt AM, Grzesiek S, Schuler B. A comprehensive structural and dynamic view of an unfolded protein from the combination of single-molecule FRET, NMR and SAXS, Proc. Natl. Acad. Sci. USA. (2016)
  • Schuler B, Soranno A, Hofmann H, Nettels D. Single-molecule FRET spectroscopy and the polymer physics of unfolded and intrinsically disordered proteins, Annu. Rev. Biophys. (2016)

2015

  • Borgia A., Kemplen K.R., Borgia M.B., Soranno A., Shammas S., Wunderlich B., Nettels D., Best R.B.,  Clarke J. and Schuler B., Transient misfolding dominates multidomain protein folding, Nat. Comm.
  • König I., Zarrin-Afsar A., Aznauryan M., Soranno A., Wunderlich B., Dingfelder F., Stüber J., Plückthun A., Nettels D., Schuler B., Single-molecule spectroscopy of protein conformational dynamics in live cells, Nature methods, 12 773-779 

2014

  • Soranno A, Koenig I, Borgia MB, Hofmann H, Zosel F, Nettels D, Schuler B. Single-molecule  spectroscopy reveals polymer effects of disordered proteins in crowded environments
    Proc. Natl. Acad. Sci. USA. 2014 vol 111 no. 13 4874-487
  •  Borgia A, Wensley B, Soranno A, Nettels D, Borgia MB, Hoffmann A, Pfeil SH, Lipman EA, Clarke J, Schuler B. Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy. Nat. Comm. 2012 3:1195

2012

  • Soranno A, Buchli B, Nettels D, Cheng RR, Müller-Späth S, Pfeil SH, Hoffmann A, Lipman EA, Makarov DE, Schuler B. Quantifying internal friction in unfolded and intrinsically disordered proteins with single molecule spectroscopy. Proc. Natl. Acad. Sci. USA. 2012 vol. 109 no. 44 17800-17806
  • Hofmann H, Soranno A, Borgia A, Gast K, Nettels D, Schuler B. Polymer scaling laws of unfolded and intrinsically disordered proteins quantified with single-molecule spectroscopy. Proc. Natl. Acad. Sci. USA. 2012;109(40):16155-60
  • Schuler B, Müller-Späth S, Soranno A and Nettels D. Application of Confocal Single-Molecule FRET to Intrinsically Disordered Proteins in“Intrinsically Disordered Protein Analysis: Volume 2, Methods and Experimental Tools (Methods in Molecular Biology) edited by Uversky VN and Dunker AK, Springer, 2012

2010

  • Müller-Späth S*, Soranno A*, Hirschfeld V, Hofmann H, Rüegger R, Reymond L, Nettels D and Schuler B. Charge interactions can dominate the dimensions of intrinsically disordered proteins. Proc. Natl. Acad. Sci. USA. 2010; 107 (33) 14609-14614

2009

  • Soranno A, Longhi R, Bellini T and Buscaglia M. Kinetics of Contact Formation and End-to-end Distance Distributions of Swollen Disordered Peptides. Biophys. J. 2009; 96(4):1515-28